反应详情

温度

80 °C

2-bromo-1,1-diethoxyethane (5.13 g) was added to a stirred mixture of cesium carbonate (8.49 g) and 2-(2-hydroxyethyl)phenol (3.00 g) in DMF (20 mL). After 5 minutes the reaction mixture was heated at 80° C. 16 h, the reaction mixture was allowed to cool and partitioned between ethyl acetate and water. The ethyl acetate layer was washed with water (×3) then evaporated. Purification by silica gel chromatography eluting with ethyl acetate:iso-hexanes, 1:3 gave the subtitle compound as a green oil. Yield 3.6 g.

1. custom16 h
2. temperatureto cool
3. custompartitioned between ethyl acetate and water
4. washThe ethyl acetate layer was washed with water (×3)
5. customthen evaporated
6. customPurification by silica gel chromatography
7. washeluting with ethyl acetate