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HRID446644

反应详情

EQUATION

反应方程式

HRID 446644 的结构方程式

REACTANTS

反应物

3
结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：COC(=O)CCOCCOCCOCCOCCNC(=O)CI
HCID86671288

未命名化合物

结构：CN(CCOc1cc(CO)nc(CO)c1)CC(C)(C)S
HCID86671289

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)CCOCCOCCOCCOCCNC(=O)CSC(C)(C)CN(C)CCOc1cc(CO)nc(CO)c1
HCID68315224

未命名化合物

收率 57.1%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

2 次

PROCEDURE

实验过程

73.7 mg of methyl 3-[2-(2-{2-[2-(2-iodoacetylamino)ethoxy]ethoxy}ethoxy)ethoxy]propanoate in solution in 1 ml of DMF and 39 μl of DIPEA are added to 45 mg of 4-{2-[(2-mercapto-2-methylpropyl)(methyl)amino]ethoxy}-2,6-bis(hydroxymethyl)pyridine in solution in 1 ml of DMF. After 24 h at AT, the mixture is concentrated under RP and purified by flash chromatography on silica (Analogix Super Flash SiO2 SF25-8 g), using a gradient from 0 to 10% of methanol in DCM. 53 mg of methyl 3-{2-[2-(2-{2-[2-(2-{[2-(2,6-bis(hydroxymethyl)pyridin-4-yloxy)ethyl](methyl)amino}-1,1-dimethylethylsulphanyl)acetylamino]ethoxy}ethoxy)ethoxy]ethoxy}propanoate are thus obtained.

WORKUP

后处理

  1. concentrationthe mixture is concentrated under RP
  2. custompurified by flash chromatography on silica (Analogix Super Flash SiO2 SF25-8 g)