Lithium Hydroxide → HCID 70896349, compound

HRID 446694Notes

Reaction equation

HRID 446694 reaction equation
C[O:2][C:3]([C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)[N:8]=[C:7]([NH:19][C:20]([C:22]2[N:26]([CH2:27][C:28]3[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][CH:29]=3)[N:25]=[C:24]([NH:36][C:37]([C:39]3[N:43]([CH2:44][C:45]4[CH:50]=[CH:49][C:48]([O:51][CH3:52])=[CH:47][CH:46]=4)[N:42]=[C:41]([N+:53]([O-:55])=[O:54])[CH:40]=3)=[O:38])[CH:23]=2)=[O:21])[CH:6]=1)=[O:4].[OH-].[Li+]>CO.C1COCC1.O>[CH3:18][O:17][C:14]1[CH:13]=[CH:12][C:11]([CH2:10][N:9]2[C:5]([C:3]([OH:4])=[O:2])=[CH:6][C:7]([NH:19][C:20]([C:22]3[N:26]([CH2:27][C:28]4[CH:29]=[CH:30][C:31]([O:34][CH3:35])=[CH:32][CH:33]=4)[N:25]=[C:24]([NH:36][C:37]([C:39]4[N:43]([CH2:44][C:45]5[CH:46]=[CH:47][C:48]([O:51][CH3:52])=[CH:49][CH:50]=5)[N:42]=[C:41]([N+:53]([O-:55])=[O:54])[CH:40]=4)=[O:38])[CH:23]=3)=[O:21])=[N:8]2)=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 12073857HCID 12073857, compound

Product 1

HCID 70896349HCID 70896349, compound

Reagents, catalysts & solvents 1

HCID 21892291Methanol tetrahydrofuran waterSolvent

Procedure

A 1.00 g (1.33 mmol, 1.00 equiv) amount of 1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-nitro-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxylic acid methyl ester [O2N-Pz(PMB)-Pz(PMB)-Pz(PMB)-OMe] and 81 mg of lithium hydroxide (3.38 mmol, 2.54 equiv) were stirred in a mixture of methanol/THF/water (5:5:1) for 18 h. The crude product is prepared according to general procedure A to yield the compound as a colorless solid. Yield: 0.92 g (1.25 mmol, 94%).

Workup

  1. customThe crude product is prepared

Sources & evidence

ORD record
ord-40f562307d1341f998b649545b119084
Source dataset
uspto-grants-2013_07
Patent number
US08481494B2

Reaction notes

Loading…