反应详情

To a 0° C. solution of 2-(4-(benzyloxy)phenyl)-2-oxo-ethyl 2-(4-methoxyphenyl)acetate (3.0 g, 0.007 mol) in DMF (20 mL) was added NaH (0.96 g, 0.01 mol). The reaction mixture was stirred at RT for 30 minutes and quenched with ice to obtain a solid precipitate. The solid precipitate was filtered and dried in vacuo to afford 4-(4-(benzyloxy)phenyl)-3-(4-methoxyphenyl)furan-2(5H)-one (2.4 g, 84%) as a solid.

1. customquenched with ice
2. customto obtain a solid precipitate
3. filtrationThe solid precipitate was filtered
4. customdried in vacuo