反应详情

温度

80 °C

To a stirred solution of 4-(4-hydroxyphenyl)-3-(4-methoxyphenyl)furan-2(5H)-one (280 mg, 0.99 mol) in DMF (5 mL) were added K2CO3 (274 mg, 1.98 mol) and 2-(chloromethyl)quinoline (255 mg, 1.19 mol) at RT. The reaction mixture was then heated at 80° C. for 3 h, quenched with ice and then extracted with EtOAc (2×20 mL). The combined organic layers were washed with water, dried over Na2SO4, and concentrated in vacuo to obtain the crude product. The crude material was purified via silica gel column chromatography using 20% ethyl acetate in hexanes to afford 3-(4-methoxyphenyl)-4-(4-(2-(quinolin-2-yl)ethyl)phenyl)furan-2(5H)-one (50 mg, 12%) as a yellow solid.

1. customquenched with ice
2. extractionextracted with EtOAc (2×20 mL)
3. washThe combined organic layers were washed with water
4. dry with materialdried over Na2SO4
5. concentrationconcentrated in vacuo
6. customto obtain the crude product
7. customThe crude material was purified via silica gel column chromatography