Hydrochloric Acid → (R)-2-AMino-N,N-diMethylpropanaMide HCl

HRID 446942Notes

Reaction equation

HRID 446942 reaction equation
C(OC(=O)[NH:7][C@@H:8]([C:10](=[O:14])[N:11]([CH3:13])[CH3:12])[CH3:9])(C)(C)C.[ClH:16]>O1CCOCC1>[ClH:16].[NH2:7][C@H:8]([CH3:9])[C:10]([N:11]([CH3:13])[CH3:12])=[O:14]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 28165234HCID 28165234, compound

Product 1

HCID 57516590(R)-2-AMino-N,N-diMethylpropanaMide HCl

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

((R)-1-Dimethylcarbamoyl-ethyl)-carbamic acid tert-butyl ester (1.1 g, 5.1 mmol) was dissolved in 26 mL of cold 4M HCl in dioxane. After 1.5 h the reaction was evaporated to provide (R)-2-amino-N,N-dimethyl-propionamide hydrochloride which was used without further purification.

Workup

  1. customAfter 1.5 h the reaction was evaporated

Sources & evidence

ORD record
ord-3f7e6a1103844b4395bf35bb14e51da2
Source dataset
uspto-grants-2013_07
Patent number
US08481541B2

Reaction notes

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