反应详情

1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine (10 g, 43.3 mmol) is combined with 3,6-dichloro-4,5-dimethyl-pyridazine (14.4 g, 84.3 mmol), triethylamine (8.25 mL), and NMP (40 mL). The reaction mixture is irradiated to a temperature of 180° C. for 25 min, and then concentrated in vacuo. The residue is purified by flash chromatography on silica gel (0-8% MeOH/CH2Cl2) to afford the title compound (13.2 g, 82%).

1. customThe reaction mixture is irradiated to a temperature of 180° C. for 25 min
2. concentrationconcentrated in vacuo
3. customThe residue is purified by flash chromatography on silica gel (0-8% MeOH/CH2Cl2)