Hydrochloric Acid → HCID 53252097, compound

HRID 447143Notes

Reaction equation

HRID 447143 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH:10][CH2:11][CH2:12][NH:13][C:14](=[O:30])[C@@H:15]([NH:22]C(=O)OC(C)(C)C)[CH2:16][C:17]1[S:18][CH:19]=[CH:20][CH:21]=1.[ClH:31]>O1CCOCC1>[ClH:31].[NH2:22][C@@H:15]([CH2:16][C:17]1[S:18][CH:19]=[CH:20][CH:21]=1)[C:14]([NH:13][CH2:12][CH2:11][NH:10][C:2]1[S:1][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=1)=[O:30]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86654765HCID 86654765, compound

Product 1

HCID 53252097HCID 53252097, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

(S)-tert-butyl 1-(2-(benzo[d]thiazol-2-ylamino)ethylamino)-1-oxo-3-(thiophen-2-yl)propan-2-ylcarbamate (195.9 mg, 0.439 mmol) was suspended in 1,4-dioxane (4 mL) and treated with 4N HCl in 1,4-dioxane (4 mL, 16.0 mmol). The resulting mixture became homogenous, then a solid separated as the stirring continued for 4 h. The solid was collected by filtration, washed with 1,4-dioxane, then dried in a vacuum oven overnight at room temperature, to yield the title compound as its corresponding hydrochloride salt, as a white solid.

Workup

  1. customa solid separated as the stirring
  2. filtrationThe solid was collected by filtration
  3. washwashed with 1,4-dioxane
  4. customdried in a vacuum oven overnight at room temperature

Sources & evidence

ORD record
ord-d4ffdf45f5aa4392ad8eae3206d86f5b
Source dataset
uspto-grants-2013_07
Patent number
US08481547B2

Reaction notes

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