Methyl iodide → 4-(4-Bromophenyl)-1-methylpiperidin-4-ol

HRID 447314Notes

Reaction equation

HRID 447314 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:14])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.CI.[C:17]([O-])([O-])=O.[K+].[K+]>CC(C)=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:14])[CH2:9][CH2:10][N:11]([CH3:17])[CH2:12][CH2:13]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 939114-(4-Bromophenyl)-4-hydroxypiperidine

Product 1

HCID 106596344-(4-Bromophenyl)-1-methylpiperidin-4-ol

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A reaction mixture of 4-(4-bromophenyl)piperidin-4-ol (1.5 g, 5.9 mmol), methyl iodide (0.4 mL, 6.4 mmol), and K2CO3 (1.2 g, 8.8 mmol) in acetone was stirred at rt for 90 min

Sources & evidence

ORD record
ord-514688907e8a4efe87421ee0af244f1a
Source dataset
uspto-grants-2013_07
Patent number
US08481533B2

Reaction notes

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