Potassium Acetate → HCID 57515478, compound

HRID 44757Notes

Reaction equation

HRID 44757 reaction equation
[C:1]([O-:4])(=[O:3])[CH3:2].[K+].[NH2:6][C:7]1[C:16]2[N:17]=[C:18]([CH2:28]Cl)[N:19]([CH2:20][C:21]3([OH:27])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)[C:15]=2[C:14]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[N:8]=1>CN(C=O)C>[C:1]([O:4][CH2:28][C:18]1[N:19]([CH2:20][C:21]2([OH:27])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]2)[C:15]2[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([NH2:6])[C:16]=2[N:17]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 517044Potassium AcetateHCID 57515471HCID 57515471, compound

Product 1

HCID 57515478HCID 57515478, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Potassium acetate (0.28 g, 2.89 mmol) was added to a solution of 1-{[4-amino-2-(chloromethyl)-1H-imidazo[4,5-c]quinolin-1-yl]methyl}cyclohexanol (0.83 g, 2.41 mmol) in DMF (10 mL). The reaction mixture was stirred at ambient temperature overnight and then concentrated under reduced pressure to provide crude [4-amino-1-(1-hydroxycyclohexylmethyl)-1H-imidazo[4,5-c]quinolin-2-yl]methyl acetate.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-2db52509f3ac42a6a489fb56ae6faa8d
Source dataset
uspto-grants-2013_09
Patent number
US08541438B2

Reaction notes

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