Hydrochloric Acid → HCID 53411782, compound

HRID 447768Notes

Reaction equation

HRID 447768 reaction equation
[F:1][C:2]1[C:7]([F:8])=[C:6]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:4][C:3]=1[CH:12](C(OCC)=O)[C:13]([O:15]CC)=[O:14].FC1C(F)=CC=C([N+]([O-])=O)C=1C(C(OCC)=O)C(OCC)=O.Cl>>[F:1][C:2]1[C:7]([F:8])=[C:6]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:4][C:3]=1[CH2:12][C:13]([OH:15])=[O:14]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 59683248Diethyl 2-(2,3-difluoro-4-nitrophenyl)malonateHCID 68625680Diethyl 2-(2,3-difluoro-6-nitrophenyl)malonate

Product 1

HCID 53411782HCID 53411782, compound

Procedure

The mixture of diethyl 2-(2,3-difluoro-4-nitrophenyl)malonate and diethyl 2-(2,3-difluoro-6-nitrophenyl)malonate from D15 (0.5 g) was heated with 11M hydrochloric acid (5 ml) at reflux overnight then evaporated to give 320 mg of the title compound (pale yellow solid) as a 1:1 mixture with 2,3-difluoro-6-nitrophenylacetic acid. M−—CO2H=172.

Workup

  1. temperatureat reflux overnight
  2. customthen evaporated

Sources & evidence

ORD record
ord-fe19fdc20b0e4130a4e18f7ead39579a
Source dataset
uspto-grants-2013_07
Patent number
US08481566B2

Reaction notes

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