Triphosgene → HCID 59683263, compound

HRID 447770Notes

Reaction equation

HRID 447770 reaction equation
[F:1][C:2]1[C:8]([F:9])=[C:7]([CH3:10])[CH:6]=[C:5]([I:11])[C:3]=1[NH2:4].Cl[C:13](Cl)([O:15]C(=O)OC(Cl)(Cl)Cl)Cl>O1CCOCC1>[F:1][C:2]1[C:8]([F:9])=[C:7]([CH3:10])[CH:6]=[C:5]([I:11])[C:3]=1[N:4]=[C:13]=[O:15]

Participants

4

Reactant 2

HCID 94429TriphosgeneHCID 596832492,3-Difluoro-6-iodo-4-methylbenzenamine

Product 1

HCID 59683263HCID 59683263, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 2,3-difluoro-6-iodo-4-methylaniline D19 (330 mg, 1.2 mmol), triphosgene (150 mg, 0.5 mmol), and dioxan (5 ml) was heated at 100° C. for 15 min then cooled and evaporated to give the crude title compound used directly in the next step.

Workup

  1. temperaturethen cooled
  2. customevaporated

Sources & evidence

ORD record
ord-307aeeb95f404af784f8c8b4effde791
Source dataset
uspto-grants-2013_07
Patent number
US08481566B2

Reaction notes

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