Hydrochloric Acid → HCID 68624356, compound

HRID 447773Notes

Reaction equation

HRID 447773 reaction equation
[F:1][C:2]1[C:10]2[NH:9][C:8](=[O:11])[N:7]([CH:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)[C:6]=2[CH:5]=[C:4]([CH3:25])[C:3]=1[F:26].[ClH:27]>ClCCl.O1CCOCC1>[ClH:27].[F:1][C:2]1[C:10]2[NH:9][C:8](=[O:11])[N:7]([CH:12]3[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]3)[C:6]=2[CH:5]=[C:4]([CH3:25])[C:3]=1[F:26]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59683267HCID 59683267, compound

Product 1

HCID 68624356HCID 68624356, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

1,1-Dimethylethyl 4-(4,5-difluoro-6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinecarboxylate D22 (150 mg, 0.4 mmol) was dissolved in dichloromethane (5 ml) and treated with HCl in 1,4-dioxane (1 ml×4M) at room temperature for 4 h. Solvent was then evaporated to afford the title compound, 120 mg. M++H=268.

Workup

  1. customSolvent was then evaporated

Sources & evidence

ORD record
ord-d039bc95c8ca488aae0caeb29bebd094
Source dataset
uspto-grants-2013_07
Patent number
US08481566B2

Reaction notes

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