Hydrochloric Acid → HCID 66969617, compound

HRID 447853Notes

Reaction equation

HRID 447853 reaction equation
[ClH:1].[NH2:2][CH2:3][C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[S:11]([N:14]([CH3:16])[CH3:15])(=[O:13])=[O:12].C([NH:20][CH2:21][C:22]1C=C(F)[CH:25]=[CH:24][C:23]=1S([Cl:32])(=O)=O)(=O)C.C[NH:34][CH3:35].Cl.[O:37]1CCCC1>>[ClH:32].[Cl:1][C:24]1[CH:23]=[C:22]([C:35]([NH2:34])=[O:37])[C:21](=[NH:20])[N:2]([CH2:3][C:4]2[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=2[S:11](=[O:12])(=[O:13])[N:14]([CH3:16])[CH3:15])[CH:25]=1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 674DimethylamineHCID 8028TetrahydrofuranHCID 66969812HCID 66969812, compoundHCID 86650830HCID 86650830, compound

Product 1

HCID 66969617HCID 66969617, compound

Procedure

(Step 1) According to the method of Example 29, Steps 2 and 3, 2-(aminomethyl)-4-fluoro-N,N-dimethylbenzenesulfonamide hydrochloride was synthesized using 2-[(acetylamino)methyl]-4-fluorobenzenesulfonyl chloride, a solution of dimethylamine in tetrahydrofuran, and hydrochloric acid.

Workup

  1. customwas synthesized

Sources & evidence

ORD record
ord-2c37ade983724f0b80634010a03e6c2d
Source dataset
uspto-grants-2013_07
Patent number
US08481569B2

Reaction notes

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