反应详情

温度

0 °C

Thiophosgene (1.1 g, 9.7 mmol) was added to a solution of 1-amino-4-cyclopropyl-naphthalene (1.8 g, 9.7 mmol) and diisopropylethylamine (2 eq) in dichloromethane (50 mL) stirred at 0° C. The reaction mixture was stirred for 5 min at this temperature, then a 1% solution of HCl in water was added and the organic layer was separated, washed with brine, dried over sodium sulfate, filtered and the solvent was evaporated under reduced pressure. Hexane was added, and the resulting precipitate was filtered. The solvent was evaporated to yield 1-cyclopropyl-4-isothiocyanatonaphthalene (1.88 g, 86%).

1. stirringThe reaction mixture was stirred for 5 min at this temperature
2. customthe organic layer was separated
3. washwashed with brine
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. customthe solvent was evaporated under reduced pressure
7. additionHexane was added
8. filtrationthe resulting precipitate was filtered
9. customThe solvent was evaporated