反应详情

To a stirred solution of isoquinoline (1-Im-9, 5 g, 1.0 eq) in 50 mL of CHCl3, mCPBA (2.0 eq) was added. The mixture was stirred at rt for 1 h. The reaction was washed with 5% aqueous Na2SO3 and aqueous Na2CO3, then concentrated and the residue was purified by silica column chromatography to give isoquinoline 2-oxide (2-Im-9).

1. washThe reaction was washed with 5% aqueous Na2SO3 and aqueous Na2CO3
2. concentrationconcentrated
3. customthe residue was purified by silica column chromatography