反应详情

温度

80 °C

A mixture of 6a (0.4 g, 1.29 mmol), 4-amino-piperidine-1-carboxylic acid tert-butyl ester (0.4 g, 1.5 eq), DMA (5 mL) and potassium carbonate (0.4 g, 2.2 eq) was heated at 80° C. for 42 h. After allowing the reaction mixture to cool down to room temperature, 100 mL of brine was added and the mixture was extracted with ethyl acetate twice (100 mL and 30 mL). The combined extracts were washed with brine (2×50 mL), dried over magnesium sulfate and filtered. The solvent was removed under vacuum to give a solution of 6b in DMA.

1. temperatureto cool down to room temperature
2. extractionthe mixture was extracted with ethyl acetate twice (100 mL and 30 mL)
3. washThe combined extracts were washed with brine (2×50 mL)
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered
6. customThe solvent was removed under vacuum