Hydrochloric Acid → HCID 66915521, compound

HRID 449051Notes

Reaction equation

HRID 449051 reaction equation
C(OC([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[N:15]=[C:16]([CH:24]3[CH2:27][CH2:26][CH2:25]3)[N:17]3[CH:22]=[CH:21][N:20]=[C:19]([NH2:23])[C:18]=23)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[CH:24]1([C:16]2[N:17]3[CH:22]=[CH:21][N:20]=[C:19]([NH2:23])[C:18]3=[C:14]([C:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH:10]=3)[N:15]=2)[CH2:27][CH2:26][CH2:25]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57960851HCID 57960851, compound

Product 1

HCID 66915521HCID 66915521, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a stirred solution of 4-(8-amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (300 mg, 1.12 mmol) in 1,4-dioxane (5 mL) was added HCl (4M solution in dioxane, 10 ml) at 10° C. The resulting mixture was stirred at rt. for 3 hr. The solvent was removed under reduced pressure and the resulting residue was used for next step without any further purification. MS (ES+): m/z: 270.13 [MH+], HPLC: tR=1.62 min (OpenLynx, polar—5 min).

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe resulting residue was used for next step without any further purification
  3. custom270.13 [MH+], HPLC: tR=1.62 min (OpenLynx, polar—5 min)

Sources & evidence

ORD record
ord-b67a7b87c8c44e9ebd223c75576c2133
Source dataset
uspto-grants-2013_07
Patent number
US08481733B2

Reaction notes

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