反应详情

温度

80 °C

A mixture of 5-bromo-2-fluoronitrobenzene (1.10 g, 5.0 mmol), phenol (0.52 g, 5.5 mmol) and K2CO3 powder (0.83 g, 5.0 mmol) in DMF (10 mL) was stirred at 80° C. for 3 h. The mixture was concentrated under reduced pressure, and the residue was partitioned between AcOEt and water. The separated organic layer was washed with 1M aqueous HCl and saturated NaCl solution. After the organic layer was dried over Na2SO4, the solvent was removed to give desired product which was used for next step without further purification.

1. concentrationThe mixture was concentrated under reduced pressure
2. customthe residue was partitioned between AcOEt and water
3. washThe separated organic layer was washed with 1M aqueous HCl and saturated NaCl solution
4. dry with materialAfter the organic layer was dried over Na2SO4
5. customthe solvent was removed