反应详情

5.93 g dronedarone hydrochloride (0.01 mol) obtained in example 1 was dissolved in 40 mL methylene chloride to obtain a mixture. Then, the mixture was adjusted to neutral pH by adding saturated sodium bicarbonate solution. The organic layer was separated and washed with saturated sodium bicarbonate solution (10 mL×2), dried over sodium sulfate and evaporated under reduced pressure to get 5.61 g of oily product.

1. customto obtain a mixture
2. customThe organic layer was separated
3. washwashed with saturated sodium bicarbonate solution (10 mL×2)
4. dry with materialdried over sodium sulfate
5. customevaporated under reduced pressure