反应详情

温度

52 °C

The obtained oily product was dissolved in 12 mL acetone to obtain a mixture, then 2 mL water were added to the mixture. Then, a solution of 1.1 mL concentrated sulfuric acid in 3 mL acetone was added dropwise under 10˜15° C. in about 20 min. Then, the mixture was heated to 52° C. and stirred for 1 h. The mixture was cooled by ice water bath under stirring for crystallization. After about 3.5 h later, lots of solid was precipitated. The solid obtained was filtered and dried at 50° C. under vacuum to obtain 5.5 g targeted compound. Yield: 84%, (Calculation by dronedarone hydrochloride), Purity of HPLC: 99.85%.

1. customto obtain a mixture
2. temperatureThe mixture was cooled by ice water bath
3. stirringunder stirring for crystallization
4. waitAfter about 3.5 h later
5. customlots of solid was precipitated
6. customThe solid obtained
7. filtrationwas filtered
8. customdried at 50° C. under vacuum
9. customto obtain 5.5 g