Hydrochloric Acid → Hydrochloric Acid

HRID 449359Notes

Reaction equation

HRID 449359 reaction equation
[ClH:1].C(OC(=O)[NH:8][C@@H:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C@@H:10]1[O:15][CH3:16])(C)(C)C>O1CCOCC1.CO>[CH3:16][O:15][C@H:10]1[CH2:11][CH2:12][CH2:13][CH2:14][C@H:9]1[NH2:8].[ClH:1]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 86645774HCID 86645774, compound

Product 2

HCID 313Hydrochloric AcidHCID 28121871HCID 28121871, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

2 mL of 4 N HCl in 1,4-dioxane was added to a solution of tert-butyl(cis-2-methoxycyclohexyl)carbamate (0.17 g, 0.74 mmol) in methanol (0.5 mL). The reaction mixture was stirred at r.t. overnight. The volatiles were removed under reduced pressure to afford the desired product as HCl salt. Analytic LCMS (M+H)+: m/z=130.1.

Workup

  1. customThe volatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-ae15371947a641dbb0efb1c65b8afa2e
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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