Methyl iodide → (1R,2S)-2-Methoxy-2,3-dihydro-1H-inden-1-amine

HRID 449365Notes

Reaction equation

C(OC(=O)[NH:7][C@@H:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10][C@@H:9]1[OH:17])(C)(C)C.[H-].[Na+].[CH3:21]I>>[CH3:21][O:17][C@H:9]1[CH2:10][C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[C@H:8]1[NH2:7]

Participants

Reactant 3

HCID 6328Methyl iodide

HCID 24758Sodium hydride

HCID 17998891tert-Butyl ((1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)carbamate

Product 1

HCID 28109796(1R,2S)-2-Methoxy-2,3-dihydro-1H-inden-1-amine

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 57, Step 2 starting from tert-butyl[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamate, sodium hydride and methyl iodide.

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-04762cc6821e4e53a87f0ec03b561b74
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08481732B2

Reaction notes

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