Triethylamine → 1246210-02-5

HRID 449372Notes

Reaction equation

HRID 449372 reaction equation
[F:1][C:2]1([F:11])[CH2:7][CH2:6][CH:5](C(O)=O)[CH2:4][CH2:3]1.C1C=CC(OP([O:24][C:25]2C=CC=CC=2)(N=[N+]=[N-])=O)=CC=1.C([N:33](CC)CC)C>C1(C)C=CC=CC=1>[F:11][C:2]1([F:1])[CH2:3][CH2:4][CH:5]([N:33]=[C:25]=[O:24])[CH2:6][CH2:7]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 123414Diphenylphosphoryl azideHCID 27791364,4-Difluorocyclohexanecarboxylic acid

Product 1

HCID 594965391246210-02-5

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 4,4-difluorocyclohexanecarboxylic acid (0.20 g, 1.2 mmol) (Matrix Scientific, Cat. #018320), diphenylphosphonic azide (0.67 g, 2.4 mmol) (Aldrich, Cat. #178756) and triethylamine (0.51 mL, 3.6 mmol) in toluene (10 mL) was refluxed overnight. The volatiles were removed under reduced pressure to afford the product which was directly used for next step reaction without further purification.

Workup

  1. temperaturewas refluxed overnight
  2. customThe volatiles were removed under reduced pressure
  3. customto afford the product which
  4. customwas directly used for next step reaction without further purification

Sources & evidence

ORD record
ord-2cc29ac6cfff4aecab4930936f6dced6
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

Loading…