2-Aminothiazole → HCID 49779702, compound

HRID 449410Notes

Reaction equation

HRID 449410 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH2:6].[C:7](Cl)(Cl)=[O:8].Cl.[CH3:12][N:13]1[CH2:18][CH2:17][N:16]([C:19]2[CH:24]=[C:23]([C:25]3[CH:34]=[C:33]4[C:28]([CH2:29][CH2:30][NH:31][CH2:32]4)=[CH:27][CH:26]=3)[N:22]=[C:21]([NH2:35])[N:20]=2)[CH2:15][CH2:14]1>>[NH2:35][C:21]1[N:22]=[C:23]([C:25]2[CH:34]=[C:33]3[C:28]([CH2:29][CH2:30][N:31]([C:7]([NH:6][C:2]4[S:1][CH:5]=[CH:4][N:3]=4)=[O:8])[CH2:32]3)=[CH:27][CH:26]=2)[CH:24]=[C:19]([N:16]2[CH2:15][CH2:14][N:13]([CH3:12])[CH2:18][CH2:17]2)[N:20]=1

Participants

4

Reactant 3

HCID 21552-AminothiazoleHCID 6371PhosgeneHCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 49779702HCID 49779702, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 40 starting from 1,3-thiazol-2-amine (Aldrich, Cat. #123129), phosgene and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=451.1.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-2f0e1db15b5546a896b9f6a690d3ddfc
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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