Hydrochloric Acid → Hydrochloric Acid

HRID 449526Notes

Reaction equation

HRID 449526 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:26]=[CH:27][CH:28]=1)[CH2:6][O:7][C:8]1[CH:17]=[C:16]2[C:11]([CH2:12][CH2:13][CH2:14][CH:15]2[NH:18]C(=O)OC(C)(C)C)=[CH:10][CH:9]=1)#[N:2].[ClH:29]>O1CCOCC1.C(#N)C>[NH2:18][CH:15]1[C:16]2[CH:17]=[C:8]([O:7][CH2:6][C:5]3[CH:4]=[C:3]([CH:28]=[CH:27][CH:26]=3)[C:1]#[N:2])[CH:9]=[CH:10][C:11]=2[CH2:12][CH2:13][CH2:14]1.[ClH:29]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 59496742HCID 59496742, compound

Product 2

HCID 313Hydrochloric AcidHCID 59496726HCID 59496726, compound

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 312751,4-DioxaneSolvent

Procedure

The tert-butyl 7-(3-cyanobenzyloxy)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamate (0.045 g) was taken up in 4 M HCl in dioxane (2 mL) at r.t. After stirring for 2 h. the reaction was concentrated under reduced pressure to give a residue. This residue was taken up in acetonitrile and reconcentrated under reduced pressure two times to give crude 3-{[(8-amino-5,6,7,8-tetrahydronaphthalen-2-yl)oxy]methyl}benzonitrile as HCl salt (0.035 g) as a solid residue.

Workup

  1. concentrationwas concentrated under reduced pressure
  2. customto give a residue

Sources & evidence

ORD record
ord-bf12cd4e8aa944cc8b161c0d531c7ad9
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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