反应详情

温度

120 °C

4 g (II) are placed in 15 ml dimethylformamide, then 4.5 ml diisopropylethylamine followed by 2.5 ml 3-fluoro-phenylamine are added. The reaction mixture is heated to 120° C. until there is no further reaction and after cooling evaporated down. The residue is mixed with water. The product is extracted with dichloromethane and purified by chromatography (silica gel, petroleum ether/ethyl acetate 80/20 to 60/40). 2.6 g (III-3) are obtained as a solid.

1. additionare added
2. customno further reaction
3. temperatureafter cooling
4. customevaporated down
5. additionThe residue is mixed with water
6. extractionThe product is extracted with dichloromethane
7. custompurified by chromatography (silica gel, petroleum ether/ethyl acetate 80/20 to 60/40)
8. custom2.6 g (III-3) are obtained as a solid