反应详情

To a solution of 4-amino acetophenone (0.5 g, 3.7 mmol) in methanol (10 ml), was added sodium borohydride (0.27 g, 7.4 mmol, 2 eq) at 0° C. The reaction mixture was stirred for 3 hr at room temperature. The solvent was evaporated and water was added. The compound was extracted with ethyl acetate, then the organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to dryness to yield pure 1-(4-amino-phenyl)-ethanol (0.4 g, 80%).

1. customThe solvent was evaporated
2. additionwater was added
3. extractionThe compound was extracted with ethyl acetate
4. dry with materialthe organic layer was dried over anhydrous sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated to dryness