反应详情

A mixture of 4-nitro benzaldehyde (500 mg, 3.31 mmol), tosylmethyl isocyanide (640 mg, 3.31 mmol) and potassium carbonate (1.37 g, 9.9 mmol) were heated to reflux in methanol (10 ml) for 2 hr. Evaporation of the solvent yielded a residue, which was diluted with water and extracted into ethyl acetate. The organic layer was washed with water and brine, dried and concentrated under reduced pressure to yield 5-(4-nitro-phenyl)-oxazole (600 mg, 95%) as solid.

1. temperaturewere heated
2. customEvaporation of the solvent
3. customyielded a residue, which
4. extractionextracted into ethyl acetate
5. washThe organic layer was washed with water and brine
6. customdried
7. concentrationconcentrated under reduced pressure