Hydrochloric Acid → HCID 67172481, compound

HRID 450111Notes

Reaction equation

HRID 450111 reaction equation
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([C:10]23[CH2:15][CH:14]2[CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11]3)=[CH:2]1.[ClH:23]>O1CCOCC1>[ClH:23].[C:10]12([C:3]3[C:4]4[C:5](=[N:6][CH:7]=[CH:8][CH:9]=4)[NH:1][CH:2]=3)[CH2:15][CH:14]1[CH2:13][NH:12][CH2:11]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67172047HCID 67172047, compound

Product 1

HCID 67172481HCID 67172481, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To tert-butyl 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)-3-azabicyclo[3.1.0]hexane-3-carboxylate (100 mg, 0.3 mmol) in dioxan (3 ml) was added 1 mL of a 4M solution of HCl in dioxan. The reaction mixture was stirred at RT for 12 h and concentrated to dryness to afford the title compound as a buff colored solid (60 mg), which was used immediately in the following step.

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-c4bafe7ad8674c308292aa6751d2fa3a
Source dataset
uspto-grants-2013_07
Patent number
US08486964B2

Reaction notes

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