反应详情

A mixture of 2,4-dichloro-5-fluoro-3 nitro-benzamide (7.00 g, 27.7 mmol), Sn(II)Cl2×2H2O (28 g, 124 mmol) and EtOAc (250 mL) is stirred for 3 h at reflux and then carefully added to a sat. aq. NaHCO3-solution (250 mL). The resulting mixture is filtered through a pad of celite, the organic phase is separated and washed with brine, dried with MgSO4 and concentrated.

1. temperatureat reflux
2. filtrationThe resulting mixture is filtered through a pad of celite
3. customthe organic phase is separated
4. washwashed with brine
5. dry with materialdried with MgSO4
6. concentrationconcentrated