Hydrochloric Acid → (S)-1-(5-Fluoropyrimidin-2-yl)ethanamine hydrochloride

HRID 450364Notes

Reaction equation

HRID 450364 reaction equation
C(OC(=O)[NH:7][C@H:8]([C:10]1[N:15]=[CH:14][C:13]([F:16])=[CH:12][N:11]=1)[CH3:9])(C)(C)C.[ClH:18]>C(Cl)Cl.O1CCOCC1>[ClH:18].[F:16][C:13]1[CH:12]=[N:11][C:10]([C@@H:8]([NH2:7])[CH3:9])=[N:15][CH:14]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58367398(S)-tert-butyl 1-(5-fluoropyrimidin-2-yl)ethylcarbamate2×

Product 1

HCID 66624037(S)-1-(5-Fluoropyrimidin-2-yl)ethanamine hydrochloride

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]carbamate (Intermediate 14, 0.21 g, 0.87 mmol) in DCM (5 ml) was added HCl (1.3 ml, 5.2 mmol) in dioxane. The reaction was stirred at room temperature for 3 hours. The solvent was removed give the title compound as white solid (quantitative). MS: Calculated: 141. Found: [M+H]+ 142.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-ec7fc2b1d72a4a5c889edc3dc106f1fe
Source dataset
uspto-grants-2013_07
Patent number
US08486966B2

Reaction notes

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