Diisopropylethylamine → HCID 68734950, compound

HRID 450384Notes

Reaction equation

HRID 450384 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([N+:9]([O-:11])=[O:10])=[C:4](F)[N:3]=1.[CH3:13][C:14]1[NH:18][N:17]=[C:16]([NH2:19])[CH:15]=1.CCN(C(C)C)C(C)C>CCO>[F:8][C:7]1[CH:6]=[C:5]([N+:9]([O-:11])=[O:10])[C:4]([NH:19][C:16]2[CH:15]=[C:14]([CH3:13])[NH:18][N:17]=2)=[N:3][C:2]=1[F:1]

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 674554212,3,6-Trifluoro-5-nitropyridine2×

Product 1

HCID 68734950HCID 68734950, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2,3,6-trifluoro-5-nitropyridine (Intermediate 40, 1.0 g) in EtOH (20 ml) at 0° C., was added 5-methyl-1H-pyrazol-3-amine (550 mg) and DIPEA (2 ml). The resulting mixture was stirred at this temperature overnight. The title compound was collected via filtration (780 mg). LCMS: 377 [M+1].

Workup

  1. filtrationThe title compound was collected via filtration (780 mg)

Sources & evidence

ORD record
ord-402068d2d797455684e34222d785e0e8
Source dataset
uspto-grants-2013_07
Patent number
US08486966B2

Reaction notes

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