Oxalyl chloride → HCID 59819913, compound

HRID 450595Notes

Reaction equation

HRID 450595 reaction equation
[F:1][C:2]([F:16])([F:15])[S:3]([C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][CH:14]=1)[C:9](O)=[O:10])(=[O:5])=[O:4].C(Cl)(=O)C([Cl:20])=O>ClCCl.CN(C)C=O>[F:1][C:2]([F:16])([F:15])[S:3]([C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][CH:14]=1)[C:9]([Cl:20])=[O:10])(=[O:5])=[O:4]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 155846983-(Trifluoromethylsulphonyl)benzoic acid

Product 1

HCID 59819913HCID 59819913, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

A solution of the product of Example 6A (198 mg, 0.8 mmol) in dichloromethane (10 mL) was stirred with oxalyl dichloride (Aldrich, 2.0 mmol) and 1 drop of dimethylformamide at ambient temperature for 2 hours. The title compound was obtained by removing the solvent under vacuum as a yellow oil (250 mg) and the compound was used directly in the next step.

Sources & evidence

ORD record
ord-b6b6275bbfcb43ffa6af08cb1a88f9bb
Source dataset
uspto-grants-2013_07
Patent number
US08486979B2

Reaction notes

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