反应详情

A solution of the product of Example 32A (320 mg, 1.23 mmol) in ethyl acetate (5 mL) was stirred with hydrochloric acid (Aldrich, 4 M in dioxane, 0.5 mL, 2.0 mmol) at ambient temperature for 4 hours. The titled compound was collected by filtration and dried under vacuum. 1H NMR (300 MHz, CD3OD) δ 7.35-7.46 (m, 1 H), 7.49-7.63 (m, 1 H), 7.93-8.07 (m, 1 H), 8.24 (dd, J=8.1, 5.8 Hz, 1 H), 9.10 (dd, J=5.8, 1.4 Hz, 1 H), 9.23 (dt, J=8.0, 1.8 Hz, 1 H), 9.66 (d, J=2.0 Hz, 1 H) ppm; MS (DCI/NH3) m/z 260 (M+H)+.

1. filtrationThe titled compound was collected by filtration
2. customdried under vacuum