Ammonia → 3-(Methylsulfamoyl)benzoic acid

HRID 450639Notes

Reaction equation

HRID 450639 reaction equation
Cl[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[CH3:14][NH2:15].N>>[CH3:14][NH:15][S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 6329MethylamineHCID 77641Benzoic acid, 3-(chlorosulfonyl)-

Product 1

HCID 2526543-(Methylsulfamoyl)benzoic acid

Procedure

The title compound was prepared according to the procedure of Example 50A using 3-(chlorosulfonyl)benzoic acid (Aldrich) and methylamine (Aldrich). 1H NMR (300 MHz, CD3OD) δ 2.54 (s, 3 H), 7.70 (t, J=7.8 Hz, 1 H), 8.02-8.07 (m, 1 H), 8.23-8.28 (m, 1 H), 8.45 (t, J=1.9 Hz, 1 H) ppm; MS (DCI/NH3) m/z 233 (M+NH4)+.

Sources & evidence

ORD record
ord-7143b1522d124eabbe7549fcead28170
Source dataset
uspto-grants-2013_07
Patent number
US08486979B2

Reaction notes

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