反应详情

温度

90 °C

In a sulfonation flask, a mixture containing 11.7 g (0.08 mol) 3-chlorothiophene-2-carbaldehyde, 48 g (0.64 mol) nitroethane, 15.4 g (0.2 mol) ammoniumacetate and 160 ml acetic acid is heated at 90° C. for 5 hours. After cooling ethylacetate is added and the organic phase washed three times with water. The organic phase is dried over sodium sulphate and after filtration the organic solvent is distilled off in a water jet vacuum. The residue is purified by column chromatography over silicagel (eluent: ethylacetate/heptane 1:5). Yield: 10.8 g (67% of theory) of a colourless oil (1H-NMR: 2.57/s/3H, 7.12/d/1H, 7.62/d/1H, 8.45/s/1H).

1. additionis added
2. washthe organic phase washed three times with water
3. dry with materialThe organic phase is dried over sodium sulphate
4. filtrationafter filtration the organic solvent
5. distillationis distilled off in a water jet vacuum
6. customThe residue is purified by column chromatography over silicagel (eluent: ethylacetate/heptane 1:5)