Hydrogen Bromide → 6-(2-aminoethyl)pyridin-2(1H)-one hydrobromide

HRID 450767Notes

Reaction equation

C[O:2][C:3]1[N:8]=[C:7]([CH2:9][CH2:10][NH2:11])[CH:6]=[CH:5][CH:4]=1.[BrH:12]>>[BrH:12].[NH2:11][CH2:10][CH2:9][C:7]1[NH:8][C:3](=[O:2])[CH:4]=[CH:5][CH:6]=1

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 212435192-(6-Methoxypyridin-2-yl)ethan-1-amine

Product 1

HCID 684507096-(2-aminoethyl)pyridin-2(1H)-one hydrobromide

Conditions

Temperature: 80 °C

Procedure

To 700 mg of 2-(6-methoxypyridin-2-yl)ethylamine was added 10 ml of a 47% aqueous hydrogen bromide solution, followed by stirring at 80° C. for 60 hours. After evaporating the solvent, the residue was washed with diethyl ether to obtain 1.21 g of a 6-(2-aminoethyl)pyridin-2(1H)-one hydrobromide as a pale brown solid.

Workup

customAfter evaporating the solvent
washthe residue was washed with diethyl ether

Sources & evidence

ORD record: ord-5a9a769524c248808e11331eb4bdd338
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08486970B2

Reaction notes

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