反应详情

A suspension of potassium carbonate (0.06 g, 4.0 mmol), 4-chloro-2-cyanophenol (0.25 g, 1.6 mmol) and ω-bromo-2-benzyloxy-acetophenone (0.49 g, 1.6 mmol) in dry DMF (10 ml) is stirred at room temperature for 20 h. After evaporating the solvent under reduced pressure the residue is taken up in ethyl acetate. The solution is washed with water, dried over sodium sulfate and evaporated under reduced pressure. The residue is purified by silical gel column chromatography to yield the title compound.

1. customAfter evaporating the solvent under reduced pressure the residue
2. washThe solution is washed with water
3. dry with materialdried over sodium sulfate
4. customevaporated under reduced pressure
5. customThe residue is purified by silical gel column chromatography