反应详情

温度

23 °C

DBU (5.48 mL, 36.3 mmol) is added dropwise to a suspension of 4-fluoro-2-methyl-1H-indol-5-ol (5.00 g, 30.3 mmol) and 2,4-dichloropyrimidine (4.60 g, 30.9 mmol) in CH3CN (60 mL) at 0° C. The resulting mixture is warmed to and stirred at 23° C. for 15 h. The reaction mixture is concentrated and the residue is partitioned between 1:1 EtOAc—CH2Cl2 (300 mL) and water (150 mL). The aqueous layer is extracted with EtOAc (2×100 mL). The combined organic layers are washed with brine (100 mL), dried (Na2SO4), and concentrated. The residue is purified by silica gel chromatography (0-100% EtOAc/heptane) to provide 5-(2-chloropyrimidin-4-yloxy)-4-fluoro-2-methyl-1H-indole.

1. temperatureThe resulting mixture is warmed to and
2. concentrationThe reaction mixture is concentrated
3. customthe residue is partitioned between 1:1 EtOAc—CH2Cl2 (300 mL) and water (150 mL)
4. extractionThe aqueous layer is extracted with EtOAc (2×100 mL)
5. washThe combined organic layers are washed with brine (100 mL)
6. dry with materialdried (Na2SO4)
7. concentrationconcentrated
8. customThe residue is purified by silica gel chromatography (0-100% EtOAc/heptane)