Hydrochloric Acid → HCID 131730713, compound

HRID 451287Notes

Reaction equation

HRID 451287 reaction equation
[ClH:1].[OH:2][C@@H:3]1[CH2:7][N:6](C(OC(C)(C)C)=O)[C@H:5]([C:15]([O:17][CH2:18][CH:19]=[CH2:20])=[O:16])[CH2:4]1>ClCCl>[ClH:1].[OH:2][C@@H:3]1[CH2:7][NH:6][C@H:5]([C:15]([O:17][CH2:18][CH:19]=[CH2:20])=[O:16])[CH2:4]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 585300471-(1,1-Dimethylethyl) 2-(2-propen-1-yl) (2S,4S)-4-hydroxy-1,2-pyrrolidinedicarboxylate

Product 1

HCID 131730713HCID 131730713, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Hydrochloric acid (4.2 M solution in dioxane, 5 mL, 21 mmol) was added to a solution of 2-allyl 1-tert-butyl (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate (1.05 g, 4.87 mmol) in dichloromethane (20 mL). The resulting mixture was stirred at room temperature for 4 hours then concentrated under vacuum to afford the title compound.

Workup

  1. concentrationthen concentrated under vacuum

Sources & evidence

ORD record
ord-e9ef578e304c4b9daa02ee2712567ab5
Source dataset
uspto-grants-2013_07
Patent number
US08487093B2

Reaction notes

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