Formic Acid → HCID 86658841, compound

HRID 451344Notes

Reaction equation

HRID 451344 reaction equation
[CH:1]1[C:6]2=[N:7][S:8][N:9]=[C:5]2[C:4]([NH:10][C:11]2[NH:15][CH2:14][CH2:13][N:12]=2)=[C:3]([Cl:16])[CH:2]=1.[CH:17]([OH:19])=[O:18]>C(O)(C)C>[CH:1]1[C:6]2=[N:7][S:8][N:9]=[C:5]2[C:4]([NH:10][C:11]2[NH:15][CH2:14][CH2:13][N:12]=2)=[C:3]([Cl:16])[CH:2]=1.[CH:17]([O-:19])=[O:18]

Participants

4

Reactant 2

HCID 284Formic AcidHCID 5487Tizanidine

Product 1

HCID 86658841HCID 86658841, compoundYield 87.5%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
2.5 °C

Procedure

3.0 g of the tizanidine base (99.15% HPLC) and 1.9 g of 99% formic acid are added to 5 ml of isopropyl alcohol; after short heating to boil a yellowish solution results, from which a precipitated product starts to separate. After cooling to 0-5° C. and aspiration 3.09 g of tizanidine formate are obtained.

Workup

  1. temperatureafter short heating
  2. customresults, from which a precipitated product starts
  3. customto separate

Sources & evidence

ORD record
ord-3cae91c09d6541ca99ef8ef3556355f8
Source dataset
uspto-grants-2013_07
Patent number
US08487113B2

Reaction notes

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