Glycolic Acid → HCID 86658844, compound

HRID 451347Notes

Reaction equation

HRID 451347 reaction equation
[C:1]([OH:5])(=[O:4])[CH2:2][OH:3].[CH:6]1[C:11]2=[N:12][S:13][N:14]=[C:10]2[C:9]([NH:15][C:16]2[NH:20][CH2:19][CH2:18][N:17]=2)=[C:8]([Cl:21])[CH:7]=1>C(O)C>[CH:6]1[C:11]2=[N:12][S:13][N:14]=[C:10]2[C:9]([NH:15][C:16]2[NH:20][CH2:19][CH2:18][N:17]=2)=[C:8]([Cl:21])[CH:7]=1.[C:1]([O-:5])(=[O:4])[CH2:2][OH:3]

Participants

4

Reactant 2

HCID 757Glycolic AcidHCID 5487Tizanidine

Product 1

HCID 86658844HCID 86658844, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
2.5 °C

Procedure

To a solution of 3.0 g of glycolic acid in 6 ml of ethanol, 3.0 g of the tizanidine base (99.15% HPLC) are added. After brief heating to boil a solution results, from which a crystalline precipitated product starts to separate. After cooling to 0 to 5° C. and aspiration 2.8 g of tizanidine glycolate are obtained.

Workup

  1. temperatureAfter brief heating
  2. customresults, from which a crystalline precipitated product starts
  3. customto separate

Sources & evidence

ORD record
ord-327becef351a4a8086625f7f7195889f
Source dataset
uspto-grants-2013_07
Patent number
US08487113B2

Reaction notes

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