HCID 67335196, compound → 3-morpholinopyridin-2-amine

HRID 451479Notes

Reaction equation

HRID 451479 reaction equation
[N+:1]([C:4]1[C:9]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[CH:8][CH:7]=[CH:6][N:5]=1)([O-])=O>C(OCC)(=O)C.[Pd]>[O:13]1[CH2:14][CH2:15][N:10]([C:9]2[C:4]([NH2:1])=[N:5][CH:6]=[CH:7][CH:8]=2)[CH2:11][CH2:12]1

Participants

4

Reactant 1

HCID 67335196HCID 67335196, compound

Product 1

HCID 574945253-morpholinopyridin-2-amine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 4-(2-nitropyridin-3-yl)morpholine (155 mg, 741 μmol) in ethyl acetate was added Pd/C 10% (15.5 mg, 146 μmol) and the reaction was hydrogenated under an atmosphere of hydrogen for 3 hours at room temperature. The catalyst was filtered off, washed with ethyl acetate and the solvent was evaporated under reduced pressure. The title compound was obtained as a purple solid (128 mg, 96%).

Workup

  1. filtrationThe catalyst was filtered off
  2. washwashed with ethyl acetate
  3. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-32f459d0445f420eb01e1820048b6ae1
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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