Hydrochloric Acid → HCID 67342611, compound

HRID 451503Notes

Reaction equation

HRID 451503 reaction equation
[CH3:1][C:2]1[N:7]=[N:6][CH:5]=[C:4]([N:8]2[CH2:13][CH2:12][CH:11]([NH:14]C(=O)OC(C)(C)C)[CH2:10][CH2:9]2)[CH:3]=1.[ClH:22]>ClCCl>[ClH:22].[ClH:22].[CH3:1][C:2]1[N:7]=[N:6][CH:5]=[C:4]([N:8]2[CH2:13][CH2:12][CH:11]([NH2:14])[CH2:10][CH2:9]2)[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67342990HCID 67342990, compound

Product 1

HCID 67342611HCID 67342611, compoundYield 121.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution tert-butyl 1-(6-methylpyridazin-4-yl)piperidin-4-ylcarbamate (2.14 g, 7.32 mmol) in dichloromethane (36 mL) was added HCl (2 M in diethylether, 18.3 mL, 36.6 mmol) and the reaction mixture was stirred at room temperature for 24 hours. The mixture was then filtered and the white precipitate was washed with dichloromethane and diethylether and dried to afford the title compound (2.35 g, 82%) as a white solid.

Workup

  1. filtrationThe mixture was then filtered
  2. washthe white precipitate was washed with dichloromethane and diethylether
  3. customdried

Sources & evidence

ORD record
ord-dfe9d1ab74a241e4b593f2a339a8eb0e
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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