Hydrochloric Acid → HCID 67342006, compound

HRID 451512Notes

Reaction equation

HRID 451512 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:8]=[C:7]([N:9]2[CH2:14][CH2:13][CH:12]([NH:15]C(=O)OC(C)(C)C)[CH2:11][CH2:10]2)[CH:6]=[CH:5][N:4]=1.Cl>ClCCl>[F:24][C:2]([F:1])([F:23])[C:3]1[CH:8]=[C:7]([N:9]2[CH2:10][CH2:11][CH:12]([NH2:15])[CH2:13][CH2:14]2)[CH:6]=[CH:5][N:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67342449tert-Butyl 1-(2-(trifluoromethyl)pyridin-4-yl)piperidin-4-ylcarbamate

Product 1

HCID 67342006HCID 67342006, compoundYield 90.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution tert-butyl 1-(2-(trifluoromethyl)pyridin-4-yl)piperidin-4-ylcarbamate (314 mg, 0.91 mmol) in dichloromethane (4.5 mL) was added HCl (2 M in diethylether, 2.27 mL, 4.55 mmol) and the reaction mixture was stirred at room temperature for 18 h. The mixture was then filtered and the white precipitate was washed with dichloromethane and diethylether and dried to afford the title compound (201 mg, 90%) as an off white solid.

Workup

  1. filtrationThe mixture was then filtered
  2. washthe white precipitate was washed with dichloromethane and diethylether
  3. customdried

Sources & evidence

ORD record
ord-cf2426507cc744f59c924eefff4d0259
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

Loading…