反应详情

To a solution tert-butyl 1-(2-(trifluoromethyl)pyridin-4-yl)piperidin-4-ylcarbamate (314 mg, 0.91 mmol) in dichloromethane (4.5 mL) was added HCl (2 M in diethylether, 2.27 mL, 4.55 mmol) and the reaction mixture was stirred at room temperature for 18 h. The mixture was then filtered and the white precipitate was washed with dichloromethane and diethylether and dried to afford the title compound (201 mg, 90%) as an off white solid.

1. filtrationThe mixture was then filtered
2. washthe white precipitate was washed with dichloromethane and diethylether
3. customdried