反应详情

温度

110 °C

To a solution of 4-fluoropiperidine hydrochloride (1.54 g, 11 mmol) and triethylamine (4.5 mL, 33 mmol) in dimethylacetamide (30 mL) was added 2-nitropyridin-3-yl trifluoro-methanesulfonate (3.00 g, 11 mmol) and the mixture heated to 110° C. for 1 hour. Water was added and the mixture extracted with ethyl acetate. The organic phase was washed with brine and dried with sodium sulfate. The solvent was evaporated in vacuo and the product used without further purification. The title compound was obtained as a yellow oil (2.22 g, 89%).

1. extractionthe mixture extracted with ethyl acetate
2. washThe organic phase was washed with brine
3. dry with materialdried with sodium sulfate
4. customThe solvent was evaporated in vacuo
5. customthe product used without further purification