HCID 2762287, compound → HCID 40429894, compound

HRID 451774Notes

Reaction equation

HRID 451774 reaction equation
C(OC([NH:8][C@@:9]([CH3:20])([CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:10]([OH:12])=[O:11])=O)(C)(C)C>C(O)(C(F)(F)F)=O.O.O=[Pt]=O>[NH2:8][C@@:9]([CH3:20])([CH2:13][CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[C:10]([OH:12])=[O:11]

Participants

4

Reactant 1

HCID 2762287HCID 2762287, compound

Product 1

HCID 40429894HCID 40429894, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 22392675Trifluoroacetic acid waterSolvent

Procedure

(S)-2-(Tert-butoxycarbonylamino)-2-methyl-3-phenylpropanoic acid (1.95 g, 6.98 mmol) was hydrogenated under H2 (50 psi), catalyzed by PtO2 (200 mg), in TFA/H2O (30/30 mL) overnight. The catalyst was filtered off and concentrated to give (S)-2-amino-3-cyclohexyl-2-methylpropanoic acid in quantitative yield. MS ESI +ve m/z 186 (M+H).

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-b10daa589dae44e8b2830bd9d0ab9093
Source dataset
uspto-grants-2013_07
Patent number
US08487108B2

Reaction notes

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