Hydrochloric Acid → HCID 58380977, compound

HRID 45189Notes

Reaction equation

HRID 45189 reaction equation
C(OC(=O)[NH:7][C:8]([CH3:17])([CH:10]1[CH2:15][CH2:14][CH:13]([OH:16])[CH2:12][CH2:11]1)[CH3:9])(C)(C)C.Cl.O>C(O)(C)C>[NH2:7][C:8]([CH:10]1[CH2:15][CH2:14][CH:13]([OH:16])[CH2:12][CH2:11]1)([CH3:17])[CH3:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 67075479[1-Methyl-1-(4-hydroxy-cyclohexyl)-ethyl]carbamic acid tert-butyl ester

Product 1

HCID 58380977HCID 58380977, compoundYield 145.3%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

580 mg of [1-Methyl-1-(4-hydroxy-cyclohexyl)-ethyl]-carbamic acid tert-butyl ester (21) were dissolved in 10 mL of isopropanol and 10 mL of 2N hydrochloric acid were added. The mixture was stirred overnight. Water was added and the isopropanol was removed in vacuo. The residue was taken up in water and lyophilized for another two times from water to give 515 mg of (22) as the hydrochloride. Rt=0.18 min (Method 5). Detected mass: 158.2 (M+H+).

Workup

  1. customthe isopropanol was removed in vacuo

Sources & evidence

ORD record
ord-56415f8ddcaa4cd199cd4e04df6744f2
Source dataset
uspto-grants-2013_09
Patent number
US08541449B2

Reaction notes

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