5-Aminobenzimidazole → HCID 178466104, compound

HRID 452060Notes

Reaction equation

HRID 452060 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]=[CH:7][NH:8][C:4]=2[CH:3]=1.[CH2:11]([O:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]=O)=[CH:16][CH:15]=1)[CH3:12].[Si](C#N)(C)(C)C.[N:28]1([C:33](N2C=CN=C2)=[O:34])C=CN=[CH:29]1>>[NH:6]1[C:5]2[CH:9]=[CH:10][C:2]([N:1]3[CH:18]([C:17]4[CH:20]=[CH:21][C:14]([O:13][CH2:11][CH3:12])=[CH:15][CH:16]=4)[CH2:29][NH:28][C:33]3=[O:34])=[CH:3][C:4]=2[N:8]=[CH:7]1

Participants

5

Reactant 4

HCID 136235-AminobenzimidazoleHCID 248344-EthoxybenzaldehydeHCID 682631,1'-CarbonyldiimidazoleHCID 82115Trimethylsilyl cyanide

Product 1

HCID 178466104HCID 178466104, compound

Procedure

The compound was synthesized starting from 5-aminobenzimidazole (0.585 g, 4.4 mmol), 4-ethoxybenzaldehyde (0.601 g, 4 mmol), TMSCN (0.5 mL, 4 mmol), PdC (10%, 0.02 g), TEA (0.98 mL, 7.0 mmol), di-(imidazol-1-yl)methanone (0.622, 3.84 mmol) as described in method 2.

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-e4683947efe74b18be444c1d981ccdf4
Source dataset
uspto-grants-2013_07
Patent number
US08486940B2

Reaction notes

Loading…